So how does exercise deliver its benefits? In 2012, Dr. Shinya Yamanaka shared the Nobel Prize for Physiology or Medicine for discovering four transcription factors — known collectively as OKSM — that can trigger gene expression that reverses aging in mature cells. The latest research suggests that one of these factors, Myc, plays a critical role in reverting muscle fibers to a more youthful state, but only in response to exercise.

Interestingly, the study authors also note that drugs some people take for life extension, such as metformin and rapamycin, may interfere with the beneficial effects of exercise on muscle. Thus, it’s important to remember that exercise is an irreplaceable part of healthy aging that a pill cannot replace.

MNT asked exercise physiologists for their tips on the best type of exercise for older adults. They recommended low impact, full-body workouts with a focus on lower body and core, as well as walking every day. In addition, people should perform strength training at least 2 days a week and mobility exercises, including stretching, every day. And it isn’t only the muscles that need a regular workout — exercise has beneficial effects throughout the body, including the brain.

To learn more about the importance of exercise, its role in slowing aging, and the best physical activities for older people, jump to “Can exercise reverse muscle aging? Yes, and this is how.”

Yamanaka factors also featured in another article this week, with the discovery by researchers at Harvard Medical School that activating 3 of the 4 genes “can safely reverse the aging process by more than 50%.” We also covered new thinking about the mystery of human consciousness, a nasal spray that may repair the damage left by stroke, and the latest development in the calorie restriction vs. intermittent fasting debate. You can find each of these and many more illuminating articles below.

Our regular daily newsletter tomorrow returns tomorrow. We’d love to hear from you in the meantime, so please send any feedback, comments, suggestions, or questions to the team by email.

By Tim Snaith
From : Newsletter Editor, Medical News Today